DRUG DESIGNING

Drug designing basically of two types namely ligand based approach or receptor based approach. In both the case the point of centre only differ but requirement of receptor and ligand essential in both the case.  

 

he shortcoming of traditional drug discovery; as well as the allure of a more deterministic approach to combating disease has led to the concept of "Rational drug design" (Kuntz 1992). Nobody could design a drug before knowing more about the disease or infectious process than past. For "rational" design, the first necessary step is the identification of a molecular target critical to a disease process or an infectious pathogen. Then the important prerequisite of "drug design" is the determination of the molecular structure of target, which makes sense of the word "rational".

In fact, the validity of "rational" or "structure-based"drug discovery rests largely on a high-resolution target structure of sufficient molecule detail to allow selectivity in the screening of compounds. Simple flowchart for drug designing shown in the figure: